Molecular geometry and biological activity of 2-(4-substituted-phenylimino)thiazolidin- 4-one compounds
نویسندگان
چکیده
ABSTRACT. A series of 2-(4-substituted-phenylimino)thiazolidin-4-one compounds was synthesized via heterocyclizing the corresponding N-aryl-2-chloroacetamides with ammonium thiocyanate. Their chemical structures were elucidated based on an extensive analysis their spectroscopic data, including infrared, 1H NMR, 13C and mass analyses. The possible tautomeric forms thiazolidine-4-ones studied. tautomerization equilibrium parameters, ΔH, ΔG, Keq calculated using DFT/B3LYP methodology, where it has been indicated that form, phenylimino, is more favourable than phenylamino form. antibacterial antioxidant properties thiazolidin-4-ones investigated. 2-(Chlorophenyl-imino)thiazolidin-4-one displayed potent activity against E. coli (88.46%) S. aureus (91.66%), highest percent inhibition (81.8%, ABTS assay).
 
 KEY WORDS: N-aryl-2-chloroacetamides, Ammonium thiocyanate, 2-(Arylimino)thiazolidin-4-ones, Mulliken’s charges, Dipole moment, assay
 Bull. Chem. Soc. Ethiop. 2023, 37(5), 1275-1286. DOI: https://dx.doi.org/10.4314/bcse.v37i5.18
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ژورنال
عنوان ژورنال: Bulletin of The Chemical Society of Ethiopia
سال: 2023
ISSN: ['1011-3924', '1726-801X']
DOI: https://doi.org/10.4314/bcse.v37i5.18